Nucleic Acid Guanine: Reaction with the Carcinogen N -Acetoxy-2-Acetylaminofluorene
- 2 September 1966
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 153 (3740) , 1125-1127
- https://doi.org/10.1126/science.153.3740.1125
Abstract
Reaction of N-acetoxy-2-acetylaminofluorene with DNA or RNA at pH 7 causes marked increase in absorption at 280 to 320 millimicrons and marked decrease in guanine content. Reaction with guanosine-8-14C yields a radioactive fluorescent derivative. The data suggest that metabolic esters of N-hydroxy-2-acetylaminofluorene may be intermediates in the binding of this proximate carcinogen to nucleic acids in vivo.This publication has 13 references indexed in Scilit:
- Reaction of esters of aromatic N-hydroxy amines and amides with methionine in vitro: A model for in vivo binding of amine carcinogens to proteinLife Sciences, 1966
- On the interaction of N-2-fluorenylhydroxylamine with nucleic acids in, vitroBiochemical and Biophysical Research Communications, 1965
- The reaction of β-propiolactone with guanosine, deoxyguanylic acid and RNABiochemical Pharmacology, 1963
- Ethionine CarcinogenesisAdvances in Cancer Research, 1963
- Toxic liver injury and carcinogenesis. Methylation of rat-liver nucleic acids by dimethylnitrosamine in vivoBiochemical Journal, 1962
- The apparent binding of radioactive 2-acetylaminofluorene to rat-liver ribonucleic acid in vivoBiochimica et Biophysica Acta, 1962
- The reaction of mono- and di-functional alkylating agents with nucleic acidsBiochemical Journal, 1961
- The reaction of mustard gas with nucleic acids in vitro and in vivoBiochemical Journal, 1960
- The bases of the nucleic acids of some bacterial and animal viruses: the occurrence of 5-hydroxymethylcytosineBiochemical Journal, 1953
- Filter-paper partition chromatography of sugarsBiochemical Journal, 1947