NATURE OF THE TWO PRESSOR RESPONSES TO ACUTE HYPOXEMIA WITH SOME OBSERVATIONS ON THE RÔLE OF THE ADRENALS IN HYPOXIA

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Abstract
The factors responsible for the pressor responses during the hypoxemic phase and in the post-hypoxemic phase were investigated. In unilaterally adrenalectomized animals, diversion into a syringe of the venous blood draining from the remaining adrenal resulted in no significant change in the hypoxemic pressor phase, but diminished considerably the post-hypoxemic response. Blood collected in the phase of the falling blood pressure during N2 breathing had markedly more pressor activity than that collected during the earlier phases of hypoxemia. Reinjection of such collected blood immediately after the peak of the post-hypoxemia response due to extra-adrenal factors caused the pressure to rise to a level similar to that attained in the control expt. It is concluded that the adrenal gland plays little part in the production of the hypoxemic pressor response, but plays a major role in the production of the arterial pressor response after re-aeration. Pressor material liberated from the adrenal during severe hypoxemia does not exert its pressor effect until the tissues are re-oxygenated.

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