The Identification of Impurities in Illicit Methamphetamine Exhibits by Gas Chromatography/Mass Spectrometry and Nuclear Magnetic Resonance Spectroscopy
- 1 January 1977
- journal article
- other
- Published by ASTM International in Journal of Forensic Sciences
- Vol. 22 (1) , 40-52
- https://doi.org/10.1520/jfs10366j
Abstract
Methamphetamine, a drug frequently abused in the United States, is often manufactured illicitly. One method commonly employed for this purpose is the Leuckart reaction, which is initiated with methyl benzyl ketone (IV) and either methylamine (I) and formic acid (II) or N-methylformamide (III), producing N-formylmethamphetamine (IX) as an intermediate [1]. Hydrolysis of IX with a strong acid such as hydrochloric acid produces methamphetamine (VI). (See Table 1 for a list of abbreviations and Fig. 1 for corresponding structures.) As the synthesis proceeds, various impurities are accumulated: reactants, byproducts, and intermediates, as well as contaminants arising from within the reagents themselves. The identification of such impurities thus far encountered in this laboratory by gas chromatography/mass spectrometry (GC/MS) and nuclear magnetic resonance (NMR) spectroscopy will be the subject of this discussion.Keywords
This publication has 15 references indexed in Scilit:
- Identification and Synthesis of di-(1-Phenylisopropyl)Methylamine, an Impurity in Illicit MethamphetamineJournal of Pharmaceutical Sciences, 1974
- Substituenteneinfluss bei der massenspektrometrischen Fragmentierung: Untersuchungen an N‐methyl‐β,β′‐diphenyl‐diäthylaminen. 19. Mitteilung über das massenspektrometrische Verhalten von StickstoffverbindungenHelvetica Chimica Acta, 1973
- Identification of a Major Impurity in MethamphetamineJournal of Pharmaceutical Sciences, 1973
- Routine detection and identification in urine of stimulants and other drugs, some of which may be used to modify performance in sportJournal of Pharmacy and Pharmacology, 1967
- Nuclear Magnetic Resonance Spectral Assignments from Nuclear Overhauser Effects1Journal of the American Chemical Society, 1965
- cis and trans Configurations of the Peptide Bond in N-Monosubstituted Amides by Nuclear Magnetic ResonanceJournal of the American Chemical Society, 1964
- Titrimetric Determination of Alkyl Mercaptan-Dialkyl Sulfide and Alkyl Mercaptan-Alkyl Disulfide MixturesAnalytical Chemistry, 1959
- Organic Ions in the Gas Phase. II. The Tropylium IonJournal of the American Chemical Society, 1957
- TEMPERATURE EFFECTS ON NUCLEAR MAGNETIC RESONANCE ABSORPTION OF HYDROGENS ATTACHED TO NITROGENJournal of the American Chemical Society, 1956
- Mass Spectra of KetonesAnalytical Chemistry, 1956