Yeast opsonization defect and immunoglobulin deficiency in severe infantile dermatitis (Leiner's disease).

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Abstract
The defect in Leiner''s disease, which presents in early infancy with extensive dermatitis, diarrhea, and failure to thrive, was attributed to a defect of the 5th component of complement (C5). Two brothers with extensive dermatitis and dysgammaglobulinemia are reported. Both died. The older showed symptoms of Leiner''s disease: C5 tests were not performed. The younger had extensive dermatitis and was found to have the C5 defect. He developed normally, but died suddenly with pertussis. The C5 defect is not the sole cause of Leiner''s disease as was suggested, but hypogammaglobulinemia or other lymphoid deficiency is also required for its expression.