Phospholipid Concentrations in Amniotic Fluid from Diabetic Pregnant Women

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Abstract
Amniotic fluid phospholipid concentrations measured in 104 samples from 65 diabetic patients were related to gestational age, the state of diabetes according to White''s classification and the development of the respiratory distress syndrome (RDS). There was statistically significant evidence of accelerated surfactant production in White classes D, F, from 34-37 wk gestation. Classes A, B, C had phospholipid concentrations not significantly different from a reference series. RDS occurred in 26% and was frequently associated with mature phospholipid concentrations. There was a significant correlation between low Apgar scores and subsequent development of RDS.

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