Red Cell Metabolic and Membrane Features in Haemolytic Anaemia of Alcoholic Liver Disease (Zieve's Syndrome)
- 1 April 1977
- journal article
- research article
- Published by Wiley in British Journal of Haematology
- Vol. 35 (4) , 573-585
- https://doi.org/10.1111/j.1365-2141.1977.tb00622.x
Abstract
Zieve's syndrome (ZS), which consists of transient haemolytic anaemia, jaundice, hyperlipoproteinaemia, and alcohol‐induced liver disease, was studied in male patients during the acute (n= 20) and the remittent (n= 10) phase. Chronic alcoholics (n= 10) without haemolysis and healthy male persons (n= 10) served as controls. Erythrocytes were separated into old and young cells by means of density‐layer centrifugation. Those fractions which contained older red cells disclosed a pyruvate‐kinase instability which resulted in impaired metabolism. Changes in membrane lipid composition as indicated by increased cholesterol and polyunsaturated fatty acids (PUFA) were also detected in patients during the acute phase of ZS. Alcohol‐induced red‐cell vitamin‐E deficiency with a decrease in PUFA levels may provoke an oxidation of reduced red‐cell glutathione which in turn results in the enzyme instability. This study lends further support to the hypothesis that the putative role of the red‐cell metabolic injury in the origin of haemolysis in ZS cannot be envisaged without introducing membrane‐linked and extracellular cofactors.This publication has 38 references indexed in Scilit:
- The effect of Na+ and K+ on glycolytic enzymes: Differential response of pyruvate kinase from dog and human erythrocytesFEBS Letters, 1975
- HEMATOLOGIC EFFECTS OF ALCOHOLAnnals of the New York Academy of Sciences, 1975
- Virus-Induced Hemolysis in Erythrocytes Deficient in Glucose-6-phosphate DehydrogenaseScience, 1968
- Mechanism of Anemia in Zieveʼs Syndrome*The Lancet Healthy Longevity, 1968
- Lipoprotein-elektrophorese in agarosegelClinica Chimica Acta; International Journal of Clinical Chemistry, 1968
- Erythrocytenisolierung aus Blut mit BaumwolleKlinische Wochenschrift, 1966
- Eine neue Bestimmung der Neutralfette im Blutserum und GewebeKlinische Wochenschrift, 1966
- The relation of hyperlipemia to hemolytic anemia in an alcoholic patientThe American Journal of Medicine, 1966
- Mikroverfahren zur Gewinnung der Fettsäuremethylester aus komplexen LipoidenAnalytical and Bioanalytical Chemistry, 1965
- Quantitative study of erythrocyte-lysolecithin interactionBiochimica et Biophysica Acta, 1963