Continuous determination of the clearance of 131-I-diatrizoate, an inulin substitute.

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Abstract
A method is presented to determine continuously glomerular filtration rate (GFR) by monitoring the renal extraction of radioiodinated (131I-) diatrizoate, an inulin substitute. Renal venous and arterial blood of anesthetized dogs infused with the isotope was circulated continuously through a dual well detectorratemeter system. Renal blood flow and artery pressure were measured continuously. GFR was calculated from the extraction ratio of the isotope and renal plasma flow. The applicability of this method in acute dog experiments was demonstrated by representative studies of renal autoregulation and infusion of the vaso-active drugs, angiotensin n, and acetylchollne. The intrarenal hemo-dynamic alterations observed agreed with results obtained by others using more conventional methods. The percent extraction of 131I-diatrizoate determined continuously averaged 20.3 [plus or minus] 0.7 in 60 observations in 12 dog experiments and compared to values of 22.4 [plus or minus] 0.8 and 23.6 [plus or minus] 0.9 for the isotope and inulin determined by the direct analysis of blood samples.

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