Characterization of Nasal Spray Pumps and Deposition Pattern in a Replica of the Human Nasal Airway
Top Cited Papers
- 1 June 2001
- journal article
- Published by Mary Ann Liebert Inc in Journal of Aerosol Medicine
- Vol. 14 (2) , 267-280
- https://doi.org/10.1089/08942680152484199
Abstract
Deposition patterns are described of a nasal spray formulation for a novel rhinovirus protease inhibitor. These patterns, which were generated from different nasal spray pumps, were characterized using a multisectional nasal airway model. A human nasal replica was made from an in vivo magnetic resonance imaging (MRI) scan of an adult male human. The nasal replica consisted of 77 acrylic plastic sections, 1.5-mm thick. Our data showed that the aerosols were deposited mainly in the anterior and turbinate regions with little passing beyond the nasopharyngeal region. Detailed deposition information from the turbinate region indicated that deposition was high toward the anterior portion where most deposition was concentrated on the inferior meatus. Spray droplets were also deposited in spots of the middle and posterior portions of the turbinate region, and this nonuniform deposition pattern may be correlated with the flow pattern. The spray angle and droplet size of the nasal spray were found to be important in influencing the deposition pattern in the nasal airway. The droplet size was determined by a laser-diffraction technique and the spray angle by high-speed photography. Larger droplets and a wider spray angle increased deposition in the anterior region of the nasal airway, which prevented more material from depositing in the turbinate region.Keywords
This publication has 8 references indexed in Scilit:
- COMPUTATIONAL FLUID DYNAMICS SIMULATIONS OF INSPIRATORY AIRFLOW IN THE HUMAN NOSE AND NASOPHARYNXInhalation Toxicology, 1998
- Increased Incidence of DNA Double-Strand Breaks in Lung and Liver of Rats After Exposure to Crocidolite Asbestos FibersInhalation Toxicology, 1994
- Morphometry of Human Nasal Airways In Vivo Using Magnetic Resonance ImagingJournal of Aerosol Medicine, 1989
- Diffusional deposition of ultrafine aerosols in a human nasal castJournal of Aerosol Science, 1988
- Effect of Viscosity on Particle Size, Deposition, and Clearance of Nasal Delivery Systems Containing DesmopressinJournal of Pharmaceutical Sciences, 1988
- The nasal distribution of metered does inhalersThe Journal of Laryngology & Otology, 1987
- Intranasal drug delivery by spray and dropsJournal of Pharmacy and Pharmacology, 1985
- A laser spectrometer for size analysis of small airborne particlesJournal of Aerosol Science, 1971