LQT4 Gene: The "Missing" Ankyrin
- 1 May 2003
- journal article
- review article
- Published by CLOCKSS Archive in Molecular Interventions
- Vol. 3 (3) , 131-136
- https://doi.org/10.1124/mi.3.3.131
Abstract
Mutations in ion channels have been implicated in the formation of long QT syndrome (LQTS). However, Mohler et al. have recently uncovered a role for ankyrin-B, a non-ion channel protein, in type IV LQTS. Calcium signalling is altered, and the functions of several channels and pumps that normally interact with wild-type ankyrin-B are impaired in the presence of mutant ankyrin-B. The authors suggest that by disrupting the functions of these channels, a new mechanism has been uncovered that can lead to cardiac myopathy.Keywords
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