Caspase activation, inhibition, and reactivation: A mechanistic view
Top Cited Papers
- 1 August 2004
- journal article
- review article
- Published by Wiley in Protein Science
- Vol. 13 (8) , 1979-1987
- https://doi.org/10.1110/ps.04789804
Abstract
Caspases, a unique family of cysteine proteases, execute programmed cell death (apoptosis). Caspases exist as inactive zymogens in cells and undergo a cascade of catalytic activation at the onset of apoptosis. The activated caspases are subject to inhibition by the inhibitor‐of‐apoptosis (IAP) family of proteins. This inhibition can be effectively removed by diverse proteins that share an IAP‐binding tetrapeptide motif. Recent structural and biochemical studies have revealed the underlying molecular mechanisms for these processes in mammals and in Drosophila. This paper reviews these latest advances.Keywords
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