Differential regulation of synaptic and extra-synaptic NMDA receptors
- 26 August 2002
- journal article
- Published by Springer Nature in Nature Neuroscience
- Vol. 5 (9) , 833-834
- https://doi.org/10.1038/nn912
Abstract
A variety of processes limit NMDA (N-methyl-D-aspartate) receptor (NMDAR) activity in response to agonist exposure, including rundown—the decline of peak current with repeated, sustained agonist application1,2,3,4. Here we report that calcium and tyrosine phosphorylation differentially regulate rundown of synaptic versus extrasynaptic NMDAR-mediated current in rat hippocampal pyramidal neurons.Keywords
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