A LOW MOLECULAR WEIGHT SUBSTANCE OBTAINED FROM SERUM WHICH HAS LUTEINIZING HORMONE LIKE ACTIVITY (“MINI LH”)

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Abstract
A low molecular weight substance of 1000-2000 daltons has been isolated in dialysates of normal human serum which, on testing in a radioimmunoassay, a radioligand receptorassay and an in-vitro bioassay exhibited LH activity comparable to the range of LH activity found in normal serum. The substance was heat labile. Its reactivity in a RIA suggests peptide nature. No “mini LH” activity could be derived from LH-free serum samples of hypophysectomized patients.

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