Batch centrifuge scale‐up for virus processing

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Abstract
The mathematical relationship between the throughput of a batch centrifuge and its mechanical characteristics has been applied to the scale‐up of one of the steps in virus processing for possible application to the production of vaccines and similar antigens. Slurries that contained a test virus were purified in a laboratory centrifuge. The Q/Σ relationship, developed by Ambler, was used to predict the operating conditions of a larger centrifuge in order to achieve the same clarification of slurry as that produced in the laboratory centrifuge. A correlation between conditions of centrifugation and amount of virus removed from the feed to the centrifuge shows that there is a well‐defined Q/Σ value at which significant concentrations of the test virus are sedimented.

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