ADDISON'S DISEASE

15 October 1932

journal article
research article
Published by American Medical Association (AMA) in JAMA

Vol. 99 (16) , 1309-1315
https://doi.org/10.1001/jama.1932.02740680005002

Abstract

For the past five years I have employed an extract, representing the active substance or hormone (interrenalin) of the adrenal¹cortex, in the treatment of Addison's disease. Sixty-two cases have come under my observation for study and treatment. This has enabled me to correlate clinical observations with my studies on adrenal insufficiency in experimental animals. In 1929, Stewart and I²published a preliminary report on the treatment of Addison's disease by oral administration of extracts prepared from the cortical layer (interrenal gland substance) of adrenal glands. At that time we reported our observations on seven patients who had been receiving "interrenalin" for periods up to about one and one-half years. In 1930, I³compared the periods of survival and clinical courses of these patients with those of patients that had not received adrenal extract. The contrast was sufficiently great to demonstrate superiority of this treatment over others

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