Coronary Artery Disease with and without Angina-Two Different Entities?

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Abstract
Coronary heart disease (CHD), previously neither diagnosed nor suspected, was strongly suspected in 115 of 2014 men aged 40-59 yr during a cardiovascular survey. Of 105 men who underwent diagnostic coronary angiography 65 had pathologic angiograms. Of these, 26 had angina pectoris (AP) with and without pathologic exercise ECG and 43 had pathologic exercise ECG as the only indicator of CHD. The extent of coronary artery changes was similar in the 2 groups. The men without AP were in almost all respects similar to 1832 men labeled as normals. The men with AP differed in several respects from their non-AP angiographic counterparts and from the normals: they had more dyspepsia, a higher stress score, higher serum cholesterol and triglycerides, lower antithrombin III levels in the blood and lower blood platelet retention values. Coronary artery disease with and without AP may represent somewhat different pathogenetic entities.