Mechanical and metabolic response of the perfused isolated fish heart to anoxia and acidosis

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Abstract
Sea raven (Hemitriperus americanus) and ocean pout (Macrozoarces americanus) hearts were excised and perfused in an isolated system. The contractile response of hearts perfused with buffer equilibrated with 100% O2, 100% N2, or 99% O2: 1% CO2 was monitored and work was calculated from mean pressure development times cardiac output. Hearts subjected to either anoxia or hypercapnic acidosis could not sustain mechanical performance as well as hearts perfused with buffer equilibrated with 100% O2. The decrease in mechanical function was not due to an unavailability of ATP. Alternatively it is suggested that contractile failure is related to a decrease in intracellular pH.

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