Advanced Glycation and Lipoxidation End Products
- 1 September 2000
- journal article
- Published by Wolters Kluwer Health in Journal of the American Society of Nephrology
- Vol. 11 (9) , 1744-1752
- https://doi.org/10.1681/asn.v1191744
Abstract
Most studies on uremic toxins have focused on disorders of enzymatic biochemistry and/or on toxins that are the result of enzymatic biochemistry. In this review, we concentrate on another aspect of uremic toxicity, related to nonenzymatic biochemistry of proteins. We investigate the causal role of various reactive carbonyl compounds (RCO) accumulating in the serum; postulate the existence of “carbonyl stress” in uremia and analyze its clinical consequences; and, finally, discuss therapeutic perspectives.Keywords
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