ESTROGEN SUPPRESSION OF SURGICALLY INDUCED VASCULAR INTIMAL HYPERPLASIA IN RABBITS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 90  (1) , 77-84
Abstract
Since estrogen reduces aortic medial hypertrophy in hypertensive rats, a naturally occurring estrogen compound, estradiol, was studied for its ability to suppress the intimal hyperplasia which follows vessel transection and anastomosis. Suture lines and adjacent abdominal aortas were examined by light microscopy and EM 1 mo. after surgery, in 23 rabbits. Test animals were given 200 .mu.g of Depoestradiol i.m. weekly, starting 3 days preoperatively. Control animals were similarly manipulated but received no estrogen. Control animals showed striking intimal thickening over the sutures, in contrast to the estrogen-treated group in which there was significantly less growth of corresponding tissue (P < 0.01).

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