THE SENSITIVITY OF BRUCELLA ABORTUS TO CHEMOTHERAPEUTIC AGENTS

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Abstract
The sensitivity of 25 strains of Brucella abortus, comprising strains of the biotypes commonly encountered in the United Kingdom, was determined to six antibiotics and co-trimoxazole (a combination of sulphamethoxasole and trimethoprim) by means of four methods, including a modification of the ditchdiffusion method. The ditch method was shown to be satisfactory for routine sensitivity testing of brucellae. The strains were almost uniformly sensitive to tetracycline, and the MIC values were between four and eight times less than the expected peak plasma levels. The strains were not as sensitive to streptomycin as those previously reported by Spink (1956), and the MIC values to this antibiotic were distributed over a wider range of concentrations than those of gentamicin or kanamycin. A comparison of MIC, peak plasma levels and plasma half-lives suggest that gentamicin and kanamycin may be more effective than streptomycin in the treatment of brucellosis when used in combination with tetracycline.

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