TLC and HPLC of Mixture of Anthracyclinones

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Abstract
A combination of TLC and HPLC [high pressure liquid chromatography] was used to separate a natural mixture of anthracyclinones/daunomycinone, 7-deoxydaunomycinone, 7-deoxy-13-dihydrodaunomycinone, 13-dihydrodaunomycinone, carminomycinone, 13-dihydrocarminomycinone, "bisanhydrocarminomycinone" and .epsilon.-rhodomycinone. The method is suitable for routine analysis of anthracyclinones in the course of their biosynthesis in production cultures and during in vitro biotransformations.