Highly diastereoselective reduction of chiral β-ketosulphoxides under chelation control: application to the synthesis of (R)-(+)-n-hexadecano-1,5-lactone
- 1 January 1985
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 4,p. 211-213
- https://doi.org/10.1039/c39850000211
Abstract
The presence of zinc chloride in the reduction of chiral β-ketosulphoxides with di-isobutylaluminium hydride effects high 1,3-asymmetric induction to give β-hydroxysulphoxides; this method can be successfully applied to the synthesis of optically pure 1,4- or 1,5-lactones.Keywords
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