The Drosophila mutation turnip has pleiotropic behavioral effects and does not specifically affect learning.
Open Access
- 1 January 1997
- journal article
- Published by Cold Spring Harbor Laboratory in Learning & Memory
- Vol. 3 (5) , 425-444
- https://doi.org/10.1101/lm.3.5.425
Abstract
The Drosophila mutant turnip (tur) was isolated on the basis of its poor performance in an olfactory learning task, and also has a reduction in protein kinase C (PKC) activity. PKC has been found in the nervous systems of a wide range of organisms and appears to have an important role in learning and memory-related processes. Unfortunately, previous reports documenting the learning defect of tur lacked the controls required to assess the origins of the poor performance of the mutant. We have analyzed the effects of the tur mutation on both associative and nonassociative learning as well as on PKC activity. Additionally, the effects of the mutation on the task-relevant sensorimotor abilities of the flies were assessed. Although we were able to replicate previous behavioral and biochemical results obtained with tur, we discovered that the tur mutation also affected response to electric shock and caused a drastic reduction in the locomotor ability of the flies. Because locomotion is an essential component of the learning assays, this result makes it impossible to conclude that tur specifically affects learning and demonstrates the crucial importance of sensorimotor controls in conditioning experiments.Keywords
This publication has 69 references indexed in Scilit:
- Spatial mapping: definitive disruption by hippocampal or medial frontal cortical damage in the ratPublished by Elsevier ,2003
- Induction of a dominant negative CREB transgene specifically blocks long-term memory in DrosophilaCell, 1994
- Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans.Psychological Review, 1992
- Characterization of the memory gene dunce of Drosophila melanogasterJournal of Molecular Biology, 1991
- On the pharmacological phenocopying of memory mutations inDrosophila: Alkylxanthines accelerate memory decayBehavior Genetics, 1991
- Learning-induced activation of protein kinase CMolecular Neurobiology, 1989
- Classical conditioning and retention in normal and mutantDrosophila melanogasterJournal of Comparative Physiology A, 1985
- Drosophila Learning: Behavior and biochemistryBehavior Genetics, 1984
- Morphology of the carnation-light synthetic lethal focus inDrosophila melanogasterCellular and Molecular Life Sciences, 1980
- Cyclic Adenosine Monophosphate in the Nervous System of Aplysia californica The Journal of general physiology, 1972