Changes in Insulin Immunoreactivity across the Coronary Circulation in Man during Infusions of Glucose and a Fat Emulsion
- 1 February 1975
- journal article
- clinical trial
- Published by Wiley in European Journal of Clinical Investigation
- Vol. 5 (1) , 57-61
- https://doi.org/10.1111/j.1365-2362.1975.tb00428.x
Abstract
The extraction of immunoreactive insulin by the human heart has been examined using the technique of coronary sinus catheterisation. The subjects were 12 male volunteers. During the study infusions of a fat emulsion and glucose were given in an effort to create a "steady fed state". The higher arterial insulin immunoreactivities which were observed during the infusions were associated with greater arterial coronary sinus differences in insulin immunoreactivity. The possibility of insulin degradation by the heart is discussed. During prolonged exercise the process of insulin removal by the heart appeared more active.Keywords
This publication has 8 references indexed in Scilit:
- MYOCARDIAL METABOLISM OF EXOGENOUS PLASMA TRIGLYCERIDES IN RESTING MANActa Medica Scandinavica, 1973
- Release of Immunoreactive Insulin from the Human HeartEuropean Journal of Clinical Investigation, 1972
- Myocardial Lipid and Carbohydrate Metabolism in Healthy, Fasting Men at Rest: Studies During Continuous Infusion of 3H‐PalmitateEuropean Journal of Clinical Investigation, 1972
- Insulin Interactions with Liver Plasma MembranesPublished by Elsevier ,1972
- Myocardial lipid and carbohydrate metabolism in fasting men during prolonged exercise.Journal of Applied Physiology, 1972
- CORONARY CIRCULATION DURING HEAVY EXERCISE IN CONTROL SUBJECTS AND PATIENTS WITH CORONARY HEART DISEASEActa Medica Scandinavica, 1971
- Radioimmunosorbent assay for proteins. Chemical couplings of antibodies to insoluble dextranImmunochemistry, 1967
- Lactic Acid Assay with L(+)lactic Acid Dehydrogenase from Rabbit MuscleActa Physiologica Scandinavica, 1963