RIFT VALLEY FEVER VIRUS HEPATITIS LIGHT AND ELECTRON MICROSCOPIC STUDIES IN THE MOUSE
- 1 June 1963
- report
- Published by Defense Technical Information Center (DTIC)
- Vol. 42 (5) , 587-+
- https://doi.org/10.21236/ad0410394
Abstract
Rift Valley fever virus produces a necrotizing hepatitis in mice that is similar to certain other virus hepatitides. The virus infects the hepatic parenchymal cells and new virus is formed in the cytoplasm within a membrane- limited system resembling the Golgi apparatus. Unique structural alterations of the ergastoplasm are associated with this process and may be manifestations of metabolic dysfunction. The acidophilic nuclear inclusion is not formed of virus matrix or virus particles and may represent a degenerative phenomenon. Changes in the Kupffer cells follow infection of the parenchymal cells.Keywords
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