Ovarian Sertoli Cell Tumors

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Abstract
Ten Sertoli cell tumors of the ovary, which occurred in patients from 2 to 62 years of age (average 38 years), are reported. Two prepubertal patients presented because of isosexual precocity, and there was evidence of estrogenic stimulation of the endometrium in two postmenopausal women. The tumors were all Stage Ia and ranged from 0.8 to 17 cm in diameter. On microscopic examination five of them contained tubules that were predominantly hollow, and five, tubules that were predominantly solid. Two of the neoplasms in the latter group were of the lipid-rich type. Seven tumors were well differentiated, two were of intermediate differentiation, and one was poorly differentiated. The last tumor, which metastasized widely and was rapidly fatal, was the only clinically malignant tumor in the series.

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