Antitumour imidazotetrazines. Part 31. The synthesis of isotopically labelled temozolomide and a multinuclear (1H, 13C, 15N) magnetic resonance investigation of temozolomide and mitozolomide
- 1 January 1995
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 3,p. 249-252
- https://doi.org/10.1039/p19950000249
Abstract
The antitumour drug temozolomide has been synthesized isotopically labelled with NMR active nuclei at a variety of sites and all its 13C and 15N NMR spectral resonances have been assigned. At low pH a site of protonation has been identified which accounts for the acid stability of the drugKeywords
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