Metampicillin

Publisher Website
Google Scholar
Abstract
Metampicillin, the penicillin prepared by the reaction of ampicillin with formaldehyde, hydrolysed in aqueous solution with the formation of ampicillin. Hydrolysis was rapid under acid conditions, less rapid in neutral medium, and was incomplete in human serum. Metampicillin showed a spectrum and level of activity similar to that of ampicillin in vitro, and both compounds were inactive against penicillinase-producing strains of bacteria. The activity of metampicillin was markedly reduced by human serum, and the compound was less active than ampicillin in the presence of human serum. Following the oral administration of metampicillin to man, metampicillin was not detected in the blood stream nor in urine, and ampicillin alone was demonstrated in these subjects. The serum concentrations of ampicillin that were produced following the oral administration of metampicillin were somewhat lower than those obtained with equivalent doses of ampicillin. Adminstration of metampicillin by the intramuscular (i.m.) route to volunteers resulted in the appearance of both ampicillin and metampicillin in the blood, and of ampicillin alone in the urine of these subjects.

This publication has 0 references indexed in Scilit: