Ketoconazole: A Novel and Rapid Treatment for Advanced Prostatic Cancer
- 1 July 1983
- journal article
- case report
- Published by Wolters Kluwer Health in Journal of Urology
- Vol. 130 (1) , 152-153
- https://doi.org/10.1016/s0022-5347(17)51007-1
Abstract
Ketoconazole is an orally administered broad-spectrum antifungal agent that acts through the inhibition of the steroid synthetic pathways. At high doses in humans ketoconazole can lower rapidly serum testosterone and maintain it in the castrate range with frequent administration. This property suggested that ketoconazole might be useful in the treatment of prostatic cancer. We report a case of prostatic cancer in which ketoconazole resulted in rapid and sustained reduction in serum androgens as well as rapid induction of a clinical remission. Ketoconazole may be a valuable agent in the treatment of prostatic cancer.Keywords
This publication has 3 references indexed in Scilit:
- Ketoconazole Blocks Adrenal Steroid SynthesisAnnals of Internal Medicine, 1982
- Ketoconazole EffectsAnnals of Internal Medicine, 1982
- Physiologic Basis for Hormonal Therapy in Carcinoma of the ProstateUrologic Clinics of North America, 1975