Fibrinogen inhibits red cell adhesion to glass

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Abstract
Studies of human erythrocyte adhesion to glass have demonstrated consistently greater adhesion with serum‐containing media than with a comparable concentration of plasma. This serum‐plasma difference is explained by the adhesion‐inhibiting property of plasma fibrinogen. The fibrinogen effect is probably mediated through its firm binding to glass, since no adsorption onto the red cell surface could be demonstrated.The ability of more red cells to adhere to a foreign surface after plasma coagulation (the formation of serum from plasma) may be significant in the red cell surface interactions necessary for the formation of a fibrin‐red cell thrombus.