Effect of body temperature reduction on response acquisition in mice

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Abstract
In four experiments designed to determine the effects of a moderate reduction of body temperature on response acquisition mice were treated with either 2,4-dichlorophenoxyacetic acid or saline in combination with cold exposure. In a four-trial water-escape problem, normothermic animals acquired the response but hypothermic mice did not show learning. A temperature-dependent relationship to learning was demonstrated. Note: (With the Technical Assistance of J. R. Blumstein)