THYROID-INHIBITING ACTION OF THE HYPOPHYSES OF RATS FED WITH THYROID

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Abstract
Hypophyses from normal rats fed the usual diet and from normal or thyroidectomized rats fed the same diet plus desiccated thyroid were suspended in saline and injected intraperit. into normal guinea pigs. The hypophyses of normal rats fed the usual diet produced in guinea pigs the following deviations from the normal: a) a 35% in-crease in the wt. of the thyroid, which presented the typical histologic picture of hyperfunction; a 9-25% increase in basal metabolism and a 28% increase in the oxidation index of the thyroid tissue. The hypophyses of normal or thyroidectomized rats fed desiccated thyroid produced a 26% decrease in wt. of the thyroid and a 26% reduction of the height of the thyroid epithelium; a 26-48% decrease in basal metabolism and a 23% decrease of the oxidation index of the thyroid tissue. The inj. of other tissues (liver, adrenals, spleen, test-is) of rats fed thyroid had no effect on the thyroid of guinea pigs. The results obtained indicate that the hypophyses of rats fed thyroid develop a thyroid-inhibiting action which causes a decrease of the basal metabolism.