Inhibition of Leishmania amastigote growth by antipain and leupeptin
- 1 January 1984
- journal article
- research article
- Published by Taylor & Francis in Pathogens and Global Health
- Vol. 78 (1) , 21-24
- https://doi.org/10.1080/00034983.1984.11811768
Abstract
Antipain and leupeptin were found to be potent inhibitors of the growth of Leishmania mexicana mexicana amastigotesin explanted mouse unstimulated peritoneal macrophages. Antipain at 100mg 1−1 reduced eight-fold the percentage of macrophages infected and to 5 % of the control the number of amastigotes present after seven days incubation. At 1 mg 1−1, antipain and leupeptin were as effective antileishmanial agents as pentamidine isethionate, all three stopping parasite multiplication over the seven-day incubation.Keywords
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