Human pancreatic and biliary responses to physiological concentrations of cholecystokinin octapeptide

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Abstract
To determine the functional significance of physiological plasma concentrations of cholecystokinin, 5 volunteers each received graded doses of i.v. infusions of cholecystokinin octapeptide (CCK-8). At each dose plasma concentrations of CCK-8 were determined and pancreatic and biliary outputs were measured. Threshold plasma concentrations of CCK-8 for augmenting pancreatic trypsin secretion were undetectable (< 3 pmol/l) and maximal trypsin output of 21.9 .+-. 1.95 k-IU [kilo-IU]/30 min was produced by 17.1 .+-. 6.4 pmol of CCK-8/l. Calculated half-maximal output was produced by 4.7 pmol of CCK-8/l. Maximal trypsin output during infusions of CCK-8 was significantly less than after combination of the CCK-like peptide, cerulein, and secretin (32.95 .+-. 2.16 k-IU/30 min, P < 0.01). Biliary bile acid and bilirubin outputs were significantly augmented only when plasma concentrations of CCK-8 were > 5 pmol/l. Plasma concentrations of CCK-8 in the low picomolar range exert significant effects on pancreatic and biliary secretion. CCK-8 fulfills the criteria for a circulating hormone.

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