Hemolysis, Elevated Liver Enzymes, and Low Platelet Count (HELLP) Syndrome as a Complication of Preeclampsia in Pregnant Women Increases the Amount of Cell-free Fetal and Maternal DNA in Maternal Plasma and Serum
Open Access
- 1 April 2002
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Chemistry
- Vol. 48 (4) , 650-653
- https://doi.org/10.1093/clinchem/48.4.650
Abstract
Fetal DNA in plasma and serum of pregnant women has been reported to be significantly increased in preeclampsia (1)(2). This increase may even precede clinical diagnosis (3). We hypothesized that subsequent development of hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome will further increase fetal DNA in maternal plasma and serum. In addition, total cell-free DNA may be increased in plasma as a result of tissue destruction, which generally occurs in HELLP syndrome.Keywords
This publication has 11 references indexed in Scilit:
- Effects of Blood-Processing Protocols on Fetal and Total DNA Quantification in Maternal PlasmaClinical Chemistry, 2001
- Elevation of both maternal and fetal extracellular circulating deoxyribonucleic acid concentrations in the plasma of pregnant women with preeclampsiaAmerican Journal of Obstetrics and Gynecology, 2001
- Successful Diagnosis of Fetal Gender Using Conventional PCR Analysis of Maternal SerumClinical Chemistry, 2001
- Increased Maternal Plasma Fetal DNA Concentrations in Women Who Eventually Develop Preeclampsia.Clinical Chemistry, 2001
- High Sensitivity of Fetal DNA in Plasma Compared to Serum and Nucleated Cells Using Unnested PCR in Maternal BloodFetal Diagnosis and Therapy, 2000
- Detection of Fetal-derived Paternally Inherited X-Chromosome Polymorphisms in Maternal PlasmaClinical Chemistry, 1999
- Quantitative Abnormalities of Fetal DNA in Maternal Serum in PreeclampsiaClinical Chemistry, 1999
- Quantitative Analysis of Fetal DNA in Maternal Plasma and Serum: Implications for Noninvasive Prenatal DiagnosisAmerican Journal of Human Genetics, 1998
- Presence of fetal DNA in maternal plasma and serumThe Lancet, 1997
- Maternal morbidity and mortality in 442 pregnancies with hemolysis, elevated liver enzymes, and low platelets (HELLP syndrome)American Journal of Obstetrics and Gynecology, 1993