DIFFERENT RESPONSES OF T-CELL SUB-POPULATIONS TO ALLERGEN CHALLENGE IN ASTHMATIC-CHILDREN AND NORMALS

  • 1 January 1980
    • journal article
    • research article
    • Vol. 44  (3) , 177-180
Abstract
Distributions of T[thymus-derived]-cell subpopulations before and after in vitro allergen stimulation were studied in 57 house dust sensitive asthmatic children and 23 healthy persons. House dust sensitivity was defined by positive skin test and RAST [radioallergosorbent test]. T.mu. cells were detected by rosette formation of T cells with ox RBC[red blood cells]-Ig[immunoglobulin]M complexes and T.gamma. cells with ox RBC-IgG complexes. Without stimulation there was no difference in distribution of T.mu. and T.gamma. cells between patients and normals. After stimulation, while T.mu. and T.gamma. cells were increased in patients, only T.gamma. cells were increased in normals. The normal IgE response of healthy individuals to allergen exposure may result from enhanced T.gamma. suppressor cells.