Evidence for a Sex Chromosome Locus for Schizophrenia
- 1 January 1989
- journal article
- review article
- Published by Oxford University Press (OUP) in Schizophrenia Bulletin
- Vol. 15 (3) , 431-440
- https://doi.org/10.1093/schbul/15.3.431
Abstract
The sex chromosomes are strong candidates for a genetic locus for schizophrenia and the affective psychoses. Gender differences in the clinical expression of illness and familial risks, concordance for gender and illness in relatives, and an association of X chromosome anomalies with psychosis suggest an X chromosome locus. The presence of male-to-male transmission in some families, in the face of a lack of strong evidence for heterogeneity, specifically focuses the search within the pseudoautosomal region of the X and Y chromosomes where sequence homology and recombination takes place.Keywords
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