EFFECTS OF GANGLIONIC BLOCKADE UPON RENAL AND CARDIOVASCULAR DYSFUNCTION INDUCED BY THERMAL INJURY

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  • 1 January 1977
    • journal article
    • research article
    • Vol. 4  (2) , 103-113
Abstract
Studies to test the effects of partial ganglionic blockade on renal and cardiovascular function were carried out in 16 mongrel dogs that under chloralose anesthesia had been subjected to full thickness flame burns to approximately 25% of their body surface. All animals received i.v. fluid replacement according to the same resuscitation formula used in burned children. Half of the animals received 0.3 mg/kg of chlorisondamine hydrochloride 40 min after the burn; the remaining 8 dogs received only the vehicle. Among the variables monitored before burning and before and after blockade were glomerular filtration rate, renal plasma flow, water and osmolar clearance, Na and K excretion, cardiac output, mean arterial, right atrial, and left ventricular end diastolic pressure, peripheral resistance, peak dP/dt/P, blood pH and blood gases. Analysis of the data revealed that pharmacologic blockade of the sympathetic system during the immediate postburn period results in a marked improvement in cardiac output and moderate improvement in kidney function.

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