Penetration of clindamycin into experimental infections with Bacteroides fragilis

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Abstract
The penetration of clindamycin into sites infected with Bacteroides fragilis was studied in an animal model in which capsules were implanted in the peritoneal cavity of rabbits. The mean percentage penetration of clindamycin ([concentration in capsule ÷ simultaneous concentration in serum] × 100) into uninfected capsules was 27·3%. In animals with infected capsules the mean percentage penetration was l3·6%. In contrast, the penetration of radiolabelled clindamycin into infected capsules was 31·8%. These results indicate that there is no alteration in capsular permeability associated with infection, but that 57% of the intracapsular clindamycin is inactivated. This inactivation may be due to tissue binding of the antibiotic or to chemical modification by bacterial or leukocytic enzymes.

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