Synthesis and Antibacterial Activity of 6-O-Arylbutynyl Ketolides with Improved Activity against Some Key Erythromycin-Resistant Pathogens
- 15 April 2003
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 46 (10) , 1795-1798
- https://doi.org/10.1021/jm025580k
Abstract
A series of novel 6-O-substituted homopropargyl ketolides was synthesized and evaluated against various erythromycin-resistant pathogens. Promising in vitro antibacterial activity was demonstrated for compounds bearing this structural motif.Keywords
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