Effects of Lidocaine on the Anesthetic Requirements for Nitrous Oxide and Halothane
Open Access
- 1 November 1977
- journal article
- research article
- Published by Wolters Kluwer Health in Anesthesiology
- Vol. 47 (5) , 437-440
- https://doi.org/10.1097/00000542-197711000-00010
Abstract
The effects of various plasma concentrations of lidocaine on N2O anesthesia in man and halothane requirements in the dog were studied. The response to incision of the skin was observed in 20 patients who were anesthetized with N2O, 70% inspired, and O2, 30%, plus various plasma levels of lidocaine. Changes in the MAC [minimal anesthetic concentration] of halothane in dogs were observed at various levels of lidocaine. In both circumstances lidocaine concentrations of 3-6 .mu.g/ml decreased anesthetic requirements approximately 10-28%. At clinically common concentrations of lidocaine, significant decreases in anesthetic requirements should be anticipated.Keywords
This publication has 5 references indexed in Scilit:
- Plasma Lidocaine Concentrations After Caudal, Lumbar Epidural, Axillary Block, and Intravenous Regional AnesthesiaAnesthesiology, 1966
- Equipotent Alveolar Concentrations of Methoxyflurane, Halothane, Diethyl Ether, Fluroxene, Cyclopropane, Xenon and Nitrous Oxide in the DogAnesthesiology, 1965
- THE SYSTEMIC ABSORPTION OF LOCAL ANALGESIC DRUGSBritish Journal of Anaesthesia, 1965
- Effect of Nitrous Oxide and Morphine on the Minimum Anesthetic Concentration of FluroxeneAnesthesiology, 1965
- Effect of Nitrous Oxide and of Narcotic Premedication on the Alveolar Concentration of Halothane Required for AnesthesiaAnesthesiology, 1964