Systemic interleukin 1 administration suppresses arachidonic acid-induced ear oedema in the mouse

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Abstract
Recombinant human interleukin 1 beta (IL-1β), given intraperitoneally to mice as a single injection, significantly suppressed the development of arachidonic acid (AA)-induced ear oedema. This effect was noted 2 h after administration and for at least 5 days afterwards. IL-Iβ was effective in the dose range of 250 ng-20 μg/mouse. Injection of IL-1βper se resulted in erythema of the ears, and thus, IL-1β has the capacity not only to induce and augment but also to suppress inflammatory responses. Indomethacin administered as subcutaneously-implanted pellets did not influence the IL-1β induced-ear erythema, but suppressed to some extent the eflect of IL-1β on the AA-induced ear oedema.