FOLLICULAR PHASE TREATMENT OF LUTEAL PHASE DEFECT WITH FOLLICLE-STIMULATING-HORMONE IN INFERTILE WOMEN

  • 1 January 1984
    • journal article
    • research article
    • Vol. 64  (1) , 32-36
Abstract
Fifteen infertile women diagnosed by endometrial dating to have a luteal phase defect were treated with human pituitary FSH (hFSH) for 45 cycles. hFSH was administered i.m. in a dose of 50 IU/day (group 1) for 35 cycles and 100 IU/day (group 2) for 10 cycles from either the 3rd or 5th day of the cycle for 5 days. Plasma estrogen was measured daily during drug injection. Plasma progesterone was measured on the 4th, 7th, and 10th days after ovulation by basal body temperature during 11 pretreatment control cycles and 39 treatment cycles. Endometrial biopsies were performed on the 7th day after ovulation. The daily estrogen levels increased gradually during hFSH treatment. There was no significant difference between the 2 dosage groups. The mean progesterone levels were: significantly (P < 0.02) greater in the treatment cycles than in the control cycles; significantly (P < 0.05) greater in the pregnancy cycles than in the nonpregnancy cycles; significantly (P < 0.01) greater in the cycles with normal endometrial dating than in the cycles with abnormal endometrial dating after treatment; and significantly (P < 0.05) greater in group 1 than in group 2. After treatment, the endometrial biopsy specimens were improved to normal in 20 of 38 cycles. Five patients became pregnant during the treatment. hFSH may be useful in treatment of luteal phase defect.

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