Total synthesis of camptotheein. I. Synthesis of ethyl 8‐(α‐chlorobutyryloxymethyl)‐7,9‐dioxo‐7,8,9,11 ‐tetrahydroindolizino[ 1,2‐a]quinoline‐8‐carboxylate and related tetracyclic compounds
- 1 June 1971
- journal article
- research article
- Published by Wiley in Journal of Heterocyclic Chemistry
- Vol. 8 (3) , 373-377
- https://doi.org/10.1002/jhet.5570080304
Abstract
A practical synthesis of the 8‐ethoxycarlbonyl‐8‐hydroxymethyl‐7,9‐dioxo‐7,8,9,11‐tetrahydro‐indolizino[ 1,2‐a]quinoline ester of α‐chlorohutyric acid, a tetracyclic intermediate for the total synthesis of the alkaloid camptothecin, was prepared from the anil of o‐aminohenzaldehyde in six steps. Preparative procedures of other related tetracyclic compounds are also reported.Keywords
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