A study of base-catalysed opening of βγ-epoxy-ketones
- 1 January 1972
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- p. 919-928
- https://doi.org/10.1039/p19720000919
Abstract
The base-catalysed isomerization of typical steroidal βγ-epoxy-ketones to the corresponding γ-hydroxy-αβ-unsaturated ketones has been studied. A mechanism for the reaction is proposed, based on kinetic data including deuterium isotope effect studies. No neighbouring hydroxy-group participation was observed in the isomerization reaction.Keywords
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