Serratia marcescens: a study of the sensitivity of British isolates to antibacterial agents and their combinations

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Abstract
The sensitivity patterns of current British isolates of Serratia marcescens to single antibacterial agents and their combinations have been investigated. The results indicate that gentamicin and amikacin are effective agents, and that co-trimoxazole appears to be an alternative worthy of further evaluation. Synergy at clinically attainable blood levels was demonstrated between trimethoprim and sulpha-methoxazole, and in fluid media (but not by agar incorporation) between both colistin and co-trimoxazole, and colistin and rifampicin. Gentamicin and co-trimoxazole were synergistic against a number of co-trimoxazole sensitive isolates. Synergy between mecillinam and other β-lactam antibiotics was observed using Mueller-Hinton agar, but not when Wellcotest agar was used.

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