Some Pharmacological Properties of a Commercial Heart Extract
- 1 September 1959
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 11 (1) , 477-484
- https://doi.org/10.1111/j.2042-7158.1959.tb12585.x
Abstract
An investigation was made of the pharmacological properties of a commercial heart extract (Recosen), said to be of value in the treatment of angina pectoris. This extract increased coronary flow but decreased force of beat in isolated perfused mammalian hearts. It potentiated the pressor effects of adrenaline in the spinal cat whilst not affecting those of noradrenaline, and it antagonised the actions of adrenaline and noradrenaline upon intestinal muscle. A mild anticholinesterase activity was demonstrated on striped muscle. The significance of these findings is discussed.Keywords
This publication has 2 references indexed in Scilit:
- Über die Wirkung von wasserlöslichen Herzextrakten auf den Stoffwechsel des HerzensKlinische Wochenschrift, 1954
- Isolation and properties of a flavoprotein from heart muscle tissueBiochemical Journal, 1939