10 year review of invasive aspergillosis detected at necropsy.
Open Access
- 1 June 1991
- journal article
- review article
- Published by BMJ in Journal of Clinical Pathology
- Vol. 44 (6) , 452-454
- https://doi.org/10.1136/jcp.44.6.452
Abstract
Between 1980 and 1989, 32 cases of invasive aspergillosis were identified out of 2315 consecutive necropsies, an incidence of 1.4%. The incidence in immunosuppressed "high risk" patients was 10.7%. Twenty out of 32 cases showed spread beyond the lungs, with the brain the most common site. There was an increase in cases in the second half of the decade, attributable to the start of a liver transplantation programme. Liver transplant recipients and patients with haematological malignancies were at significantly greater risk of acquiring aspergillosis than kidney transplant recipients or those with solid malignancies treated with chemotherapy. There was also a greater risk of haematogenous dissemination in liver transplant recipients than in all other groups, and this was significantly associated with the use of high dose steroids as anti-rejection treatment. Aspergillus was isolated during life in only eight cases, which indicates a continuing need for and emphasises the value of necropsy.Keywords
This publication has 10 references indexed in Scilit:
- Cerebral aspergillosis in liver transplantation.Journal of Clinical Pathology, 1990
- Comparison of immunodiffusion and enzyme linked immunosorbent assay for antibodies to four Aspergillus species.Journal of Clinical Pathology, 1989
- New drugs for systemic fungal infections.BMJ, 1989
- Continual audit of clinical diagnostic accuracy by computer: A study of 592 autopsy casesThe Journal of Pathology, 1987
- Fungal infections of the central nervous systemNeurology, 1985
- FUNGAL INFECTIONS IN LIVER TRANSPLANT RECIPIENTSTransplantation, 1985
- IgG enzyme linked immunosorbent assay for diagnosis of invasive aspergillosis: retrospective study over 15 years of transplant recipients.Journal of Clinical Pathology, 1985
- Pulmonary infiltrates in immunocompromised patients: diagnosis by cytological examination of bronchoalveolar lavage fluid.Journal of Clinical Pathology, 1984
- DISSEMINATED ASPERGILLOSIS OCCURRING IN PATIENTS WITH RESPIRATORY, RENAL, AND HEPATIC FAILUREThe Lancet, 1982
- Central Nervous System Infection in the Chronically ImmunosuppressedMedicine, 1982