Intraepithelial lymphocytes and macrophages in the normal breast
- 1 January 1985
- journal article
- research article
- Published by Springer Nature in Virchows Archiv
- Vol. 407 (4) , 369-378
- https://doi.org/10.1007/bf00709984
Abstract
In this study the presence of intraepithelial cells within the normal breast parenchyma was investigated by electron microscopy and immunocytochemistry. Cells were observed which could be differentiated from the epithelial and myoepithelial cells by their cytoplasmic and nuclear morphology and the absence of cell junctions. Two cell types (lymphocytes and macrophages) were identified ultrastructurally and the bone marrow origin of the cells was confirmed by immunocytochemistry. The intraepithelial lymphocytes and macrophages were present in all samples irrespective of the physiological state. In the “resting”, pregnant, and lactating breast the majority of cells were lymphocytes while in the involuting breast there was a marked increase in the proportion of macrophages. The rarity of lymphoma of the breast may be related to the relatively small amount of lymphoid tissue present and the passive nature of the environment.Keywords
This publication has 33 references indexed in Scilit:
- Diagnosis of Human Lymphoma with Monoclonal Antileukocyte AntibodiesNew England Journal of Medicine, 1983
- Resting human female breast tissue produces iodinated proteinsJournal of Ultrastructure Research, 1983
- A technique for identifying areas of interest human breast tissue before embedding for electron microscopy.Journal of Clinical Pathology, 1981
- Boosting of Secretory IgA Antibody Responses in Man by Parenteral Cholera VaccinationScandinavian Journal of Immunology, 1977
- Atrophy and apoptosis in the cyclical human endometriumThe Journal of Pathology, 1976
- Ultrastructural studies on prostatic involution in the rat. Evidence for focal irreversible damage to epithelium, and heterophagic digestion in macrophagesJournal of Ultrastructure Research, 1972
- Intraepithelial cells in the human intestinal mucosaJournal of Ultrastructure Research, 1971
- Studies on mammary gland involution: II. Ultrastructural evidence for auto- and heterophagocytosisJournal of Ultrastructure Research, 1968
- Studies on mammary gland involution: I. On the ultrastructure of the lactating mammary glandJournal of Ultrastructure Research, 1968
- Observations on the ultrastructure of a mammary ductuleJournal of Ultrastructure Research, 1967