Synthesis of isotopically chiral [13C]penciclovir (BRL 39123) and its use to determine the absolute configuration of penciclovir triphosphate formed in herpes virus infected cells
- 1 January 1990
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 7,p. 555-556
- https://doi.org/10.1039/c39900000555
Abstract
Isotopically chiral [13C]penciclovir (BRL 39123) has been synthesised via a stereospecific hydrolysis catalysed by the lipase from Candida cylindraceae and has been used to determine, by 13C NMR, that the triphosphate of penciclovir formed in herpes simplex type 1 infected cells has (S) stereochemistry with an enantiomeric purity of > 95%.Keywords
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