A Rapid Screening Procedure for Acidic and Neutral Drugs in Blood by High Resolution Gas Chromatography

1 January 1987

journal article
research article
Published by Oxford University Press (OUP) in Journal of Analytical Toxicology

Vol. 11 (1) , 8-11
https://doi.org/10.1093/jat/11.1.8

Abstract

A rapid high resolution gas chromatographic method for screening acidic and neutral drugs in blood is described. The procedure involves a single extraction with ethyl acetate. Using flame ionization detection, without derivatization and with on-column methylation, more than 60 drugs of toxicologic importance are detected.

Keywords

METHYLATION
IONIZATION
CHROMATOGRAPHY
RESOLUTION
COLUMN
DERIVATIZATION
PROCEDURE
ACETATE
NEUTRAL
TOXICOLOGIC

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